Morphogenesis of the vertebrate brain

Our group is interested in the molecular and cellular mechanisms underlying morphogenesis of the vertebrate brain, and in the perturbations of these processes in human diseases affecting brain development. 

  • Our main project aims at dissecting the functions of the primary cilium in brain morphogenesis using the mouse and zebrafish as model systems. Primary cilia are microtubular organelles with sensory functions, whose defects lead to human diseases called ciliopathies. We investigate the functions of Ftm/Rpgrip1l, a ciliopathy gene encoding a protein of the ciliary transition zone, in brain morphogenesis, cell behaviour and signalling pathways.

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Our group is interested in the molecular and cellular mechanisms underlying morphogenesis of the vertebrate brain, and in the perturbations of these processes in human diseases affecting brain development. We are more particularly interested in studying cell polarity processes and the dynamic localisation of intracellular cues and the function of organelles such as cilia.

  • The main project of the group aims at dissecting the functions of the primary cilium in brain morphogenesis using the mouse and zebrafish as model systems. Primary cilia are microtubular organelles with sensory functions, whose defects lead to human diseases called ciliopathies. We mainly focus on the Ftm/Rpgrip1l gene, which codes for a ciliary protein and is involved in severe ciliopathies with associated brain abnormalities. We investigate the function of this gene in brain morphogenesis, cell behaviour and signalling pathways.