A cloak of invisibility for glutamate

Glutamate is the major neurotransmitter in the mammalian brain. Glutamate receptors are widely distributed in the central nervous system and are crucial in learning and memory.

In this article published in the journal PNAS, the researchers have developed a new "caged" glutamate with biological and photochemical properties that enable, for the first time, experiments in behaving mice. 

This article was the subject of a news item on the INSB website.

Figure: A) Principle of caged glutamates and caged glutamate protected by the cape. B) Opto-fluidic approach to deliver the caged compound and light to a region of the brain of a behavioural mouse. C) The mouse spends more time on the light-associated side (right) than on the control side (without light, left), as shown by the mouse trajectory (black line).