Master Project 2020-2021 - How does cAMP control oocyte meiotic divisions?

Cell division is a fundamental process for the reproduction, development, growth and maintenance of living organisms. This process is orchestrated by the universal cell division kinase, Cdk1-Cyclin B (or MPF for M-phase promoting factor). Our project aims to elucidate the molecular circuits regulating this key enzyme that enables the initiation of cell division. We are using meiotic divisions of Xenopus oocytes as a model system. [...]


Post-doc Position - August 28, 2019

A post-doctoral position is available in Dominique Weil's team "Compartmentation and intracellular trafficking of mRNPs". We are seeking a highly motivated candidate trained in molecular and cellular biology to be part of the ANR-funded project: "P-bodies in cell cycle control". [...]


2 Postdoctoral Positions in Machine Learning and Neurodegenerative Disease Modelling

Applications are invited for 2 postdoc positions in machine learning available at the Brain-C Lab in the Institute of Biology Paris-Seine. The positions are supported for 2 years starting October-November 2019 with possible renewal for a third year.

  • Postdoc position 1 is focused on probability and statistics.
  • Postdoc position 2 is focused on bioinformatics and programming. [...]


[FILLED] POSTDOCTORAL POSITION AVAILABLE: Telomere biology in the green algae Chlamydomonas reinhardtii

Project overview:

Telomeres are repeated sequences found at the end of the linear chromosomes of most eukaryotes and are required for chromosome integrity. They shorten with each cell division and expression of the reverse transcriptase telomerase allows for de novo addition of telomeric repeats, counteracting telomere shortening. Although Chlamydomonas reinhardtii, a photosynthetic unicellular green alga, is widely used as a model organism in photosynthesis and flagella research, as well as for biotechnological applications, the biology of its telomeres has not been investigated in depth. [...]


3 years PhD position on the mechanisms of adult chronic exposure to phthalates in the male brain

The research project will be carried out under the supervision of S. Mhaouty-Kodja at the “Neuroplasticity of Reproductive Behaviors » team (Sorbonne Université – Institut de Biologie Paris-Seine, Neurosciences Paris-Seine, CNRS UMR 8246 / INSERM U1130, Paris).

Application deadline: 15th October 2018

Starting date: 1st January 2019 

Project description : [...]


Investigation of the role of a ciliopathy gene in familial idiopathic scoliosis: from zebrafish to human

Idiopathic Scoliosis (IS) is a human pathology characterised by a severe curvature of the axial skeleton without any obvious ossification defect, which affects 3% of the population, mainly girls, before puberty. Because its etiology remains mysterious, no genetic test or medication is available to either predict or stop its progression. Similar scoliotic phenotypes have been recently described in zebrafish mutant for a ciliary motility gene “Curly” and for the Wnt signalling co-receptor PTK7 suggesting links between cilia, the Wnt-pathway and scoliosis (1). Cilia are cellular antennae that support many functions: fluid propulsion and transduction of light, chemical and mechanical signals. [...]


Master-2 Project 2018-2019 : Functional analysis of Shroom proteins during pronephros morphogenesis in Xenopus

Chronic kidney disease (CKD) affects 750 million people around the world. Mutation of Shroom 3  has been identified in Human and mice associated with CKD but also neural tube closure defect. Shroom3 encodes an intracellular protein located at adherent junctions where it generates contractile forces by controlling the distribution of Myosin II downstream of the PCP pathway. [...]


[filled] Post-doc in Reproductive Biology

We are looking for a postdoctoral candidate to work on mitochondrial inheritance. We are interested in understanding the cell and developmental mechanisms of uniparental and maternal mitochondrial genome inheritance. The lab is currently investigating how sperm mitochondria are targeted for degradation and how maternal cotnributionr emains homoplasmic throughout generations. We are using live imaging and genetic screens on C. elegans to tackle these two fundamental questions. [...]


Applications for a PhD position in Neuroscience

The team « Neuroplasticity of Reproductive Behaviors » is looking for a candidate to present to the « Cerveau Cognition Comportement » doctoral school, on a project which aims to study the neuroepigenetic modifications induced by the environmental exposition to endocrine disruptors. [...]