5 MAI 2017 - 13H

Proteopathic seeds in neurodegenerative diseases

Mathias Jucker, German Center for Neurodegenerative Diseases, DZNE, Tübingen, Allemagne.

Lieu : Amphi Charpak (LPNHE), niveau RdC, tour 22, campus Jussieu.

Résumé : The commonality of many neurodegenerative disorders is the predictable temporal occurrence and progression of specific aggregated proteins in the brain. The hallmark proteopathy is Alzheimer’s disease in which aggregated amyloid-β peptide (Aβ) is deposited in the brain parenchyma (amyloid plaques), and aggregated Tau protein forms neuronal inclusions (neurofibrillary tangles). Multiple evidence suggests that Aβ and Tau aggregates can spread within and among brain regions and act as corruptive templates (seeds) that induce a chainreaction of misfolding and aggregation of cognate proteins. The same appears true for α-synuclein aggregates in α-synucleinopathies. The insight that the prion paradigm also applies to Alzheimer´s disease and other age-related neurodegenerative diseases suggests new directions in search of biomarkers and novel therapeutic strategies.

Le site web du laboratoire de Mathias Jucker