Séminaire externe de l'IBPS - Molecular mechanisms of social competence

7 février 2020 - 13h30

Claudia Bagni, Université de Lausanne, Faculté de Biologie et de Médecine, Département des neurosciences fondamentales, Suisse

Lieu : Amphithéâtre Charpak

Abstract: Individuals with the 15q11.2 microdeletions, which include the CYFIP1 gene, can present with a diverse array of symptoms such as neurobehavioral disturbances, epilepsy and psychiatric problems. The core behavioral features and the underlying molecular mechanisms of this genetic condition, however, remain unclear. In brain, CYFIP1 regulates synapse structure and plasticity by orchestrating at last two processes: actin remodeling and protein synthesis. I will discuss how Cyfip1 haploinsufficiency causes deficits in functional brain connectivity and behaviour and the molecular and cellular mechanisms underlying those deficits. Finally, I will discuss the importance of our findings for other neurodevelopmental disorders.


Séminaire externe de l'IBPS