Séminaire IBPS : Understanding cellular heterogeneity

03 MARS 2017 - 13H

Understanding cellular heterogeneity

Sarah Teichmann, EMBL-EBI, Cambridge, Royaume-Uni.

Lieu : Amphithéâtre Durand (Bâtiment Esclangon), Campus Jussieu.

Résumé : From techniques such as microscopy and FACS analysis, we know that many cell populations harbour heterogeneity in morphology and protein expression. With the advent of high throughput single cell RNA-sequencing, we can now quantify transcriptomic cell-to-cell variation. I will discuss technical advances and biological insights into understanding cellular heterogeneity in T cells and ES cells using single cell RNA-sequencing.

Sarah Teichmann is interested in global principles of regulation of gene expression and protein complexes, specifically in the context of immunity. Sarah did her PhD at the MRC Laboratory of Molecular Biology, Cambridge, UK and was a Beit Memorial Fellow at University College London. She started her group at the MRC Laboratory of Molecular Biology in 2001. In 2013, she moved to the Wellcome Trust Genome Campus in Hinxton/Cambridge, jointly with the EMBL-European Bioinformatics Institute and the Wellcome Trust Sanger Institute (WTSI). In January 2016 she became Head of the Cellular Genetics Programme at the WTSI. Sarah is an EMBO member and a Fellow of the Academy of Medical Sciences, and her work has been recognized by a number of prizes, including the Lister Prize, Biochemical Society Colworth Medal, Royal Society Crick Lecture and EMBO Gold Medal.

Plus d'informations : Laboratoire de Sarah Teichmann