[POURVU] POSTDOCTORAL POSITION AVAILABLE: Telomere biology in the green algae Chlamydomonas reinhardtii

Project overview:

Telomeres are repeated sequences found at the end of the linear chromosomes of most eukaryotes and are required for chromosome integrity. They shorten with each cell division and expression of the reverse transcriptase telomerase allows for de novo addition of telomeric repeats, counteracting telomere shortening. Although Chlamydomonas reinhardtii, a photosynthetic unicellular green alga, is widely used as a model organism in photosynthesis and flagella research, as well as for biotechnological applications, the biology of its telomeres has not been investigated in depth. [...]


Poste d'ingénieur d'étude, contrat CDD de un an renouvelable, à partir de janvier-février 2019

Un poste d'ingénieur d'étude (H/F), en contrat CDD de un an renouvelable (sur financement ANR), est à pourvoir à partir de janvier-février 2019 au sein de l'équipe Vieillissement Cellulaire et Inflammation dans l’UMR 8256 de l’Institut de Biologie Paris-Seine. [...]


3 years PhD position on the mechanisms of adult chronic exposure to phthalates in the male brain

The research project will be carried out under the supervision of S. Mhaouty-Kodja at the “Neuroplasticity of Reproductive Behaviors » team (Sorbonne Université – Institut de Biologie Paris-Seine, Neurosciences Paris-Seine, CNRS UMR 8246 / INSERM U1130, Paris).

Application deadline: 15th October 2018

Starting date: 1st January 2019 

Project description : [...]


Investigation of the role of a ciliopathy gene in familial idiopathic scoliosis: from zebrafish to human

Idiopathic Scoliosis (IS) is a human pathology characterised by a severe curvature of the axial skeleton without any obvious ossification defect, which affects 3% of the population, mainly girls, before puberty. Because its etiology remains mysterious, no genetic test or medication is available to either predict or stop its progression. Similar scoliotic phenotypes have been recently described in zebrafish mutant for a ciliary motility gene “Curly” and for the Wnt signalling co-receptor PTK7 suggesting links between cilia, the Wnt-pathway and scoliosis (1). Cilia are cellular antennae that support many functions: fluid propulsion and transduction of light, chemical and mechanical signals. [...]


Master-2 Project 2018-2019 : Functional analysis of Shroom proteins during pronephros morphogenesis in Xenopus

Chronic kidney disease (CKD) affects 750 million people around the world. Mutation of Shroom 3  has been identified in Human and mice associated with CKD but also neural tube closure defect. Shroom3 encodes an intracellular protein located at adherent junctions where it generates contractile forces by controlling the distribution of Myosin II downstream of the PCP pathway. [...]


Stage Master : Modélisation de la dynamique temporelle des divisions des cellules précurseurs neurales au sein de l'épithélium dorsal de la drosophile. Responsable: Michel Gho

Les soies mécanosensorielles qui couvrent la partie dorsale du thorax de la drosophile sont formées au sein de l'épithélium à partir de cellules précurseurs. Ces dernières sont organisées en rangées, s’étendant sur toute la longueur, parallèles à la ligne médiane. Ces cellules précurseurs restent arrêtées environ 10 heures en phase-G2 puis entrent en division pour générer les cellules formant chaque soie sensorielle. [...]


Projet thèse équipe Breau

Marie Breau, qui vient de créer une jeune équipe affiliée au Laboratoire de Biologie du Développement à l’IBPS et au Laboratoire Jean Perrin (Physique) et Alain Trembleau (Lab. Neuroscience Paris Seine, IBPS) recherchent un(e) très bon(ne) candidat(e) à présenter au concours de l'Ecole Doctorale Complexité du Vivant. [...]


Exploring the function of an RNA methyl transferase (RMT) involved in non-coding RNA silencing pathways (mi, si &piRNA).

Three classes of small non-coding RNAs (sncRNA) emerged as a vast silencing framework in metazoan. They are involved in numerous biological processes including development, defense against pathogens and transposable element as well as chromatin dynamics. Precursors of these three types of small RNAs, namely miRNAs (microRNA)siRNAs (small interfering RNA) and piRNAs (piwi interacting RNA) are all transcribed by RNA polymerase II. After distinct biogenesis processes, si, pi and miRNAs are all loaded inside Argonaute proteins and guide them to target RNAs with sequence complementarity. The post-transcriptional repression that will take place using these ribonucleoprotein complexes (RNA-Induced Silencing Complexes, RISC) can operate through endonucleolytic cleavage or translational repression of the target RNA. Argonaute proteins loaded with si or piRNA are also involved in transcriptional repression by recruiting, at nascent RNAs, complexes that are able to modify DNA or histone proteins. These varieties of functional and mechanistic outputs explain why misregulation of RNA silencing pathways has been correlated to the emergence of cancer, neurodegenerative diseases and infertility troubles. [...]