Genome biology

Our research projects aim at understanding the biology and the evolution of eukaryotic genomes. We are combining an experimental approach on yeast species based on molecular genetics and functional genomics to an analytical exploration of genome sequences requiring bio-informatic skills and the development of new tools.

We study genome dynamics through the characterization of the structural variations of chromosomes and sequence polymorphisms at different scales, from cells to populations, and from strains and to different species.

We are interested by the relationships between replication/recombination and the evolution of gene content, of gene organization along chromosomes and of protein sequences.

We also seek for the molecular mechanisms responsible for chromosomal rearrangements and for the variations of the nucleotide composition within and between genomes.

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Team themes:

  • Synteny and reconstruction of ancestral genomes
  • Evolution of the spatio-temporal replication profiles of genomes
  • Characterization of the molecular mechanisms involved in the formation of chromosomal rearrangements
  • Characterization of genetic determinants controlling genome stability
  • Study of the natural genetic diversity and variations of nucleotide composition of genomes
  • Patterns and rates of protein sequence evolution
  • Phylogeny of genes, genomes and species

Collaborations

  • IRCAN, Nice France - Gianni Liti
  • Institut Pasteur Paris – Romain Koszul
  • Université de Strasbourg – Joseph Schacherer
  • INRA AgroParisTech, Grigon – Cécile Neuvéglise
  • CNRS Marseille – Bertrand Llorente
  • Isoft, Gif sur Yvette
  • Stowers Institute for Medical Research, Kansas city, USA – Rong Li