Phenotypic control of vascular smooth muscle cells (VSMC)

Atherosclerosis is the cause of most heart attacks and strokes, and is per excellence, a disease of ageing and there are growing evidences for a pivotal role of VSMC phenotypic switching in atherosclerosis. Although the mechanisms controlling VSMC phenotypic modulation in pathological vascular remodelling have largely been studied, the selection of specific molecular targets modulating a signalling pathway attributable to particular functions is still needed. 

Based on our results, our 1st objective is to characterize the functional role of AC8 in pathological vascular remodellings including atherosclerosis and restenosis post-angioplasty; it will also specify the AC8-induced cAMP dynamics and the AC8-dependant signaling pathways involved in trans-differentiated VSMC responses. 

Taking advantage of our background acquired on peripheral large arteries), our 2nd goal is to decipher molecular mechanisms underlying the cellular phenotypic changes disrupting cerebro-vascular integrity in the aged brain.

Collaborations

  • Dr P. Vincent, UMR 8256, Biology of Adaptation and Aging (B2A), Paris, France.
  • Dr O. Meilhac, Unité INSERM 1148 "Laboratory for Vascular Translational Science"
  • Dr M. Lafargue, INSERM U1048, Toulouse, France.
  • Dr V. S. Golubkov, Cancer Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California, USA.
  • Dr R. Rota, Angiogenesis Laboratory, Ospedale Pediatrico Bambino Gesù, Roma, Italy.
  • Dr R. Bobe, Inserm U770, Le Kremin-Bicêtre, France
  • Dr Jochen Lang: Université de Bordeaux, CNRS UMR 5248, Pessac, France.
  • Dr Larissa Lipskaia UMR 955 - "Institut Mondor de Recherche Biomédicale "IMRB", Créteil, France.