Brain-C Lab: Compensation systems in neurodegenerative diseases and aging

Understanding brain cell compensation trajectories may open new avenues to fighting neurodegenerative diseases and age-related pathologies.

REGISTRATION NOW OPEN: EMBO workshop'Network Inference in Biology and Disease', September 2019, Naples, Italy.

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NEUROFRANCE 2019: Join us in Marseille to hear the latest research on exocytosis and extracellular vesicle signaling in brain development, maintenance, and disease!

Symposium supported by the Société des Neurosciences (Neurofrance 2019) and co-supported by the Société de Biologie Cellulaire Française (SBCF) and Société Française de Microscopie.

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Our primary goal is to understand how the capacity of the brain cell systems to maintain function and resist neurodegenerative disease is regulated on molecular, cellular and inter-cellular levels, and how this may impact on the progression of neurodegenerative disease processes and how these mechanisms may be targeted for stopping or slowing down these diseases. We study these questions in Huntington's disease (HD), a genetic and tractable neurodegenerative disease for which well-characterized models and high dimensional datasets are available across species, with the transfer of knowledge to other diseases such as Alzheimer's disease (AD).

related goal of our laboratory is to use our multi-disciplinary expertise to identify resilience factors in neurodegenerative diseases (HD, AD) and age-related stress.

Our knowledge discovery model is based on combined use systems modeling, cell biology, genetics, and clinical research.

To understand how neurodegenerative diseases may work on a system level, we developed BioGemix —a data integration framework based on combining several machine learning approaches— and we use it for basic research and clinical discovery purposes.

Experimental biology involves cellular models such as mouse neurons and human iPSC stem cells, and C. elegans genetics.

We access human disease cohort data through our network of collaborators.

We work with the European HD Network (EHDN), APHP, the Gerontopole Ile-de-France, the Paris Region initiative'Longevity and aging', Inserm, Sorbonne Université and CNRS.

We promote a research model based on a multi-disciplinary and trans-sectorial strategic platform able to study several aspects of age-related diseases, addressing the following questions:

  • What are the most important systems compensation mechanisms in neurodegenerative diseases? How to target these mechanisms in order to stop the progression of neurodegenerative diseases such as HD and AD?
  • What are the factors allowing to predict the individual capacity for biological resilience in neurodegenerative disease and age-related stress? Along these lines, what are the molecular diagnosis and precision medicine markers allowing to predict the most likely course of neurodegenerative disease progression rate and the most likely course of functional recovery upon age-related stress?


Modélisation et BioGemix :


Association et réseaux :

Association Huntington France :

Euro-HD :