COMPENSATION SYSTEMS IN NEURODEGENERATIVE DISEASE AND AGING - Brain-C

Understanding brain compensation systems may open new avenues to fighting neurodegenerative diseases and age-related pathologies.

Our primary goal is to understand how the capacity of the brain to maintain function and resist neurodegenerative disease (brain compensation) is regulated on molecular, cellular and inter-cellular levels, and how this may impact on the dynamics of neurodegenerative disease processes over time. The FOXO family of transcription factors is central to stress response, cell survival and longevity. We study the role of FOXO factors, their targets and mechanisms engaged by these targets in Huntington's disease, a genetic and tractable neurodegenerative disease.

related goal of our laboratory is to use of our expertise to study and predict biological resilience to acute and chronic stress in aging.

Our knowledge discovery model is based on the combined use systems modelling and experimental. To understand how neurodegenerative diseases may work at the dynamic and system levels, we developed BioGemix —a data integration framework based on graph theory— and use it for basic research and clinical discovery purposes. Cell biology in the lab involves the use of mouse and human iPS cell models and C. elegans genetics. We access animal models and human disease cohorts through our network of collaborators.

We work with the European HD Network (EHDN), APHP’s University Hospital Department « Fight Aging and Stress » (DHU FAST), Gerontopole Ile-de-France, UPMC, Inserm and EIT/KIC « Health » to address questions as follows:

  • What are the most important compensatory mechanisms in neurodegenerative diseases such as Huntington's disease? How are they regulated during the disease process ?
  • What are the factors allowing to predict the individual capacity for biological resilience in neurodegenerative disease and age-related stress ? 

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Modélisation et BioGemix : http://www.hdinhd.org/

DHU FAST : http://www.dhu-fast.org/

Association et réseaux :

Association Huntington France : http://huntington.fr/

Euro-HD : https://www.euro-hd.net/html/network/groups/biomodifiers