New regulators of hematopoietic stem cells identified

Charles Durand and Thierry Jaffredo1, at the IBPS (UMR 7622) recently showed that stromal cells, known to regulate hematopoietic stem cells (HSCs), secrete extracellular vesicles (EVs) specifically captured by HSCs. These vesicles harbor a complex molecular signature, different from the original cells, and contain coding and non-coding RNAs. Stromal EVs maintain the survival and potential of HSCs, presumably by protecting them from programmed cell death, and also influence their genetic expression profile. Published in The Journal of Cell Biology, these results2 open the way for targeting normal and pathologic HSCs by molecules of therapeutic interest.

This study has been featured online on the INSB website as well as in the CNRS newsletter En direct des labos.

  1. Team Migration and differentiation of hematopoietic stem cells (UMR 7622)
  2. Extracellular vesicles of stromal origin target and support hematopoietic stem and progenitor cells, The Journal of Cell Biology, 2017.