Computational prediction of dimeric transcription factor complexes

November 27th, 2018 - 11AM

Jerzy Tiuryn, Faculty of Mathematics, Informatics and Mechanics University of Warsaw, Warsaw, Poland

Location: LCQB Kitchen, building C, 4th floor, Jussieu campus

Abstract: The binding of transcription factors (TFs) to their specific motifs in genomic regulatory regions is commonly studied in isolation. However, in order to elucidate the mechanisms of transcriptional regulation, it is essential to determine which TFs bind DNA cooperatively as dimers and to infer the precise nature of these interactions. We will discuss an algorithm for predicting cell-type–specific TF–TF dimerization on DNA on a large scale, using DNase I hypersensitivity cell-type-specific data

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