Josquin Courte

  • Address Cassan, bâtiment B, étage 6, porte 614, case courrier 12, 7 quai Saint Bernard, 75 252 PARIS CEDEX
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Resumé

Josquin Courte is a PhD student in the team "Degenerative Processes in Neurons and Networks" within UMR 8256 (CNRS-UPMC, IBPS). He obtained a Master of Expertise in Biotechnologies at Sup’Biotech (Villejuif, France) and a Master of Research in Neuroscience (Master BI, UPMC) in 2015. He did his Master 1 and Master 2 internships under the direction of Jean-Michel Peyrin, on a system for controlling protein stability separately in the axons and somas of cultured neurons, and on the neuroprotective properties of proteins from neurotropic viruses, respectively.

Josquin is currently working on the dissemination of prion-like phenomenons in neuronal networks. He is focusing on alpha-synucleinopathies such as Parkinson ’s disease, dementia with Lewy bodies or Multiple System Atrophy, where neuropathological events (protein aggregation and neuronal death) propagate slowly following neuronal connections. 

Recent work has indicated that alpha-synuclein, the main component of the protein aggregates in these pathologies, could have a prion-like behavior similar to the one of the PrP protein, responsible for Creutzfeldt-Jakob’s disease. As many of the efforts towards treating these pathologies have focused on the functional consequences of disease progression rather than stopping the spreading of the disease, it is of paramount importance to understand how the later occurs.

For this purpose, Josquin is using microfluidic directional co-culture systems developed in the laboratory. These devices allow for the precise manipulation of different parameters that may be important for neuron-to-neuron transmission of protein aggregation and possible induced toxicity: 1) synaptic integrity, 2) neuronal activity and 3) network topology (neuronal subtypes and geometry).